A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/127 (2006.01) A61K 31/663 (2006.01)
Patent
CA 2530460
The present invention relates to methods and compositions designed for the treatment or management of acute coronary syndromes, particularly, unstable angina and acute myocardial infarction. The methods of the invention comprise the administration of an effective amount of a formulation containing one or more therapeutic agents which specifically decreases or inhibits the activity of phagocytic cells and/or eliminates or diminishes the amount of phagocytic cells including, but not limited to, macrophages and monocytes. The formulations are specifically targeted to phagocytic cells. The invention also provides pharmaceutical compositions of formulations containing one or more therapeutic agents of the invention for administration to subjects currently suffering from or having recently suffered an acture coronary syndrome such as unstable angina and acute myocardial infarction.
Cette invention se rapporte à des procédés et à des compositions conçus pour traiter ou prendre en charge des syndromes coronariens aigus, tels que notamment l'angor instable et l'infarctus du myocarde aigu. Ces procédés consistent à administrer une quantité efficace d'une formulation contenant un ou plusieurs agents thérapeutiques qui diminuent ou inhibent spécifiquement l'activité des cellules phagocytaires et/ou qui éliminent ou diminuent la quantité des cellules phagocytaires, telles que notamment les macrophages et les monocytes. Ces formulations sont spécifiquement ciblées sur les cellules phagocytaires. Cette invention concerne également des compositions pharmaceutiques de formulations contenant un ou plusieurs agents thérapeutiques faisant l'objet de cette invention, en vue de leur administration à des sujets souffrant présentement ou ayant récemment souffert d'un syndrome coronarien aigu, tel qu'un angor instable ou un infarctus du myocarde aigu.
Danenberg Haim D.
Edelman Elazer R.
Golomb Gershon
Richter Yoram
Biorest Ltd.
Kirby Eades Gale Baker
LandOfFree
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