Method of treating airway diseases with beta-adrenergic...

A - Human Necessities – 61 – K

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A61K 31/138 (2006.01) A61K 31/137 (2006.01) A61K 31/192 (2006.01) A61K 31/403 (2006.01) A61K 31/46 (2006.01) A61K 31/47 (2006.01) A61K 31/522 (2006.01) A61K 31/56 (2006.01)

Patent

CA 2544611

The use of .beta.-adrenergic inverse agonists provides a new and highly efficient way of treating a number of pulmonary airway diseases, including asthma, emphysema, and chronic obstructive pulmonary diseases. In general, such a method comprises administering a therapeutically effective amount of a .beta.-adrenergic inverse agonist to the subject to treat the pulmonary airway disease. Particularly preferred inverse agonists include nadolol and carvedilol.

L'invention concerne l'utilisation d'agonistes inverses .beta.-adrénergiques constituant une nouvelle manière hautement efficace de traiter un grand nombre de maladies des voies pulmonaires, notamment, l'asthme, l'emphysème, et des maladies pulmonaires obstructives chroniques. En général, une telle méthode consiste à administrer une quantité thérapeutiquement efficace d'un agoniste inverse .beta.-adrénergique à un sujet pour traiter la maladie de ses voies pulmonaires. En particulier, des agonistes inverses préférés comprennent le nadolol et le carvedilol.

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