A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) A61K 9/00 (2006.01) A61K 9/28 (2006.01) A61K 31/192 (2006.01) A61K 31/22 (2006.01) A61K 31/366 (2006.01) A61K 31/40 (2006.01) A61K 31/401 (2006.01) A61K 31/404 (2006.01) A61K 31/4418 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01) G01N 33/68 (2006.01) A61K 9/20 (2006.01)
Patent
CA 2389973
Methods for the treatment and prevention of APP processing disorders such as Alzheimer's disease and Down's Syndrome which are based on the administration of an effective amount of a HMG-CoA reductase inhibitor to a mammal are disclosed. Additionally, methods for the treatment and prevention of APP processing disorders such as Alzheimer's disease and Down's Syndrome which are based on the reduction of cellular cholesterol in a mammal are disclosed. These methods reduce the amount of A.beta. peptides or decrease the formation of A.beta. peptides or increase the clearance of A.beta. peptides in a mammal suffering from Alzheimer's disease and Down's Syndrome.
La présente invention concerne des méthodes de traitements et de prévention des troubles de maturation moléculaire APP (protéine précurseur amyloïde), notamment la maladie d'Alzheimer et le syndrome de Down, consistant à administrer à un mammifère une dose efficace d'un inhibiteur de réductase HMG-CoA. De plus, cette invention concerne des méthodes de traitement et de prévention des troubles de maturation moléculaire APP, notamment la maladie d'Alzheimer et le syndrome de Down, consistant à réduire le taux de cholestérol cellulaire chez le mammifère. Ces méthodes réduisent la quantité de peptides A.beta., réduisent la formation de peptides A.beta. ou stimule l'élimination des peptides A.beta. chez un mammifère souffrant de la maladie d'Alzheimer ou du syndrome de Down.
Buxbaum Joseph
Friedhoff Lawrence
Andrx Corporation
Buxbaum Joseph
Friedhoff Lawrence
Gowling Lafleur Henderson Llp
LandOfFree
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