A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/407 (2006.01) A61K 31/167 (2006.01) A61K 31/192 (2006.01) A61K 31/404 (2006.01) A61K 31/56 (2006.01) A61K 31/663 (2006.01) A61K 38/18 (2006.01) A61P 19/02 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01) C12N 9/02 (2006.01)
Patent
CA 2474431
Methods of treating and preventing bone loss and/or enhancing bone formation are disclosed. The methods utilize 15-lipoxygenase inhibitors. These molecules can be delivered alone or in combination with agents which inhibit bone resorption or additional agents that regulate calcium resorption from bone or enhances bone accumulation. The invention additionally provides methods of diagnosing a predisposition to bone loss.
La présente invention concerne des procédés pour traiter et prévenir la perte osseuse et/ou améliorer la formation osseuse. Ces procédés mettent en oeuvre des inhibiteurs de 15-lipoxygénase. Ces molécules peuvent être administrées seules ou associées à des agents qui inhibent la résorption osseuse ou à d'autres agents qui régulent la résorption de calcium des os ou qui améliorent l'accumulation osseuse. La présente invention concerne également des procédés pour diagnostiquer une prédisposition à la perte osseuse.
Allard John David
Klein Robert Frederick
Peltz Gary Allen
F. Hoffmann-La Roche Ag
Gowling Lafleur Henderson Llp
Oregon Health & Science University
Oregon Health And Science University
The Government Of The United States Department Of Veterans Affairs
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