A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 38/21 (2006.01) A61P 25/28 (2006.01) A61P 37/02 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2490804
Disclosed is a method of administering an interleukin-2 receptor (IL-2R) antagonist to a subject to treat an autoimmune disease. In particular embodiments, the IL-2R antagonist is an anti-IL-2R monoclonal antibody specific for one or more chains of the IL-2R, such as the alpha-chain, for example daclizumab. In other particular embodiments the autoimmune disease is multiple sclerosis. In certain embodiments administration of interferon-beta is combined with administration of an antagonist of the IL-2R to provide significant clinical improvement in a subject with an autoimmune disease.
L'invention porte sur un procédé d'administration de l'antagoniste du récepteur d'interleukine-2 (IL-2R) à un sujet afin de traiter une maladie auto-immune. Dans des modes de réalisation particuliers, l'antagoniste du IL-2R est un anticorps monoclonal de l'anti-IL-2R propre à au moins une chaîne du IL-2R, telle que la chaîne alpha, par exemple daclizumab. Dans d'autres modes de réalisation particuliers, la maladie auto-immune est une sclérose en plaques. Dans certains modes de réalisation, l'administration d'interféron bêta est combinée à celle d'un antagoniste du IL-2R afin de fournir une nette amélioration clinique chez un sujet atteint d'une maladie auto-immune.
Bielekova Bibiana
Martin Roland
Mcfarland Henry F.
Waldmann Thomas
Smart & Biggar
The Government Of The United States Of America As Represented By
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