Method of treating benign forgetfulness

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/205 (2006.01) A61K 31/122 (2006.01) A61K 31/198 (2006.01) A61K 31/221 (2006.01) A61K 31/385 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2389623

Disclosed herein are methods to treat cognition disorders, particularly those associated with aging. The method comprises administering a combination of a carnitine and an oxidant. Preferably the oxidant is thioctic acid. Preferably 0.12 grams to 3 grams of carnitine (particularly ALC) and 0.12 and 1.5 grams of R-(-lipoic acid are administered. Optionally, coenzyme Q and/or creatine also are administered. Preferably 10 mg to 500 mg/day of coenzyme Q10 and 1 to 30 grams/day of creatine are administered. The same method can be used to treat cognition deficits associated with carbon monoxide poisoning, mild traumatic brain injury, Type 2 diabetes mellitus, obsessive-compulsive disorder, environmental toxin exposure, and other conditions.

L'invention concerne des méthodes permettant de traiter les troubles cognitifs, en particulier les troubles liés au vieillissement. La méthode consiste à administrer une combinaison de carnitine et d'oxydant. De préférence, l'oxydant est de l'acide thioctique. De préférence, on administre entre 0,12 grammes et 3 grammes de carnitine (en particulier de la carnitine acétyle-L) et entre 0,12 et 1,5 grammes d'acide lipoïque R-.alpha.. Eventuellement, on administre, de la coenzyme Q et/ou de la créatine. De préférence, on administre de 10 mg à 500 mg/jour de coenzyme Q10 et de 1 à 30 grammes/jour de créatine. La même méthode peut être utilisée pour traiter des troubles cognitifs associés à l'empoisonnement au monoxyde de carbone, à une lésion cérébrale traumatique bénigne, au diabète sucré de type 2, aux troubles obsessivo-compulsifs, à une exposition aux produits toxiques pour l'environnement, et à d'autres affections.

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