Method of treating blindness with hnt human neuronal cells

A - Human Necessities – 01 – N

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A01N 63/00 (2006.01) A61K 35/30 (2006.01) A61K 35/12 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2280820

Disclosed herein is the treatment for blindness in a mammal by transplanting an effective amount of pluripotent stem cells, neuronal stem cells or hNT neuron. The treatment can be accomplished by injecting the cells into the retinal area of the eye. Additionally, the cells can be injected into the visual cortex of the brain. Conditions which can be treated are vision loss due to optic nerve damage, including glaucoma, optic nerve sheath meningioma and glioma, Graves' ophthalmopathy, orbital tumors, metastatic lesions, tumors arising from the adjacent paranasal sinuses or middle cranial fossa, giant pituitary adenomas, brain tumors or abscesses, cerebral trauma or hemorrhage, meningitis, arachnoidal adhesions, pseudotumor cerebri, cavernous sinus thrombosis, dural sinus thrombosis, encephalitis, space-occupying brain lesions, severe hypertensive disease or pulmonary emphysema, and retinal degeneration, particularly age-related macular degeneration.

La présente invention concerne un traitement de la cécité chez un mammifère par greffe d'une quantité efficace de cellules souches multipotentes, de cellules souches neuronales ou du neurone hNT. On peut effectuer le traitement par injection des cellules dans l'aire rétinienne de l'oeil. En outre, il est possible d'injecter les cellules dans le cortex visuel du cerveau. Les états pouvant être traités sont une perte de la vue due à une détérioration du nerf optique, notamment le glaucome, le méningiome et le gliome de la gaine du nerf optique, l'ophtalmopathie de Graves, les tumeurs orbitaires, les lésions métastatiques, les tumeurs des cavités annexes des fosses nasales adjacentes ou de la fosse cérébrale moyenne, les adénomes pituitaires géants, les tumeurs ou abcès du cerveau, le trauma cérébral ou l'hémorragie cérébrale, la méningite, les adhésions arachnoïdiennes, la méningite séreuse, la thrombose des sinus caverneux, la thrombose des sinus duraux, l'encéphalite, les lésions cérébrales occupant l'espace, l'affection hypertensive ou l'emphysème pulmonaire graves et la dégénérescence rétinienne, en particulier la dégénérescence maculaire liée au vieillissement.

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