A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/7084 (2006.01) A61K 9/00 (2006.01) A61P 11/00 (2006.01) A61P 11/10 (2006.01) A61P 11/12 (2006.01)
Patent
CA 2271126
A method of promoting clearance of retained mucous secretions in the bronchi, bronchioles and small terminal airways of a subject in need of such treatment is disclosed. The method comprises administering to the bronchi of the subject a uridine phosphate such as uridine 5'~triphosphate (UTP), or P1,P4-di(uridine-5~) tetraphosphate (U2P4), an analog of UTP, or any other analog, in an amount effective to promote mucociliary clearance and/or cough clearance of retained fluid in the bronchi, bronchioles and small terminal airways. Methods of administering the same would include; aerosol inhalation, any liquid suspension (including nasal drops or spray), oral form (liquid or pill), injected, intra-operative instillation or suppository form.
L'invention concerne un procédé facilitant l'expéctoration de sécrétions de mucus retenues dans les bronches, les bronchioles et les petites voies aériennes terminales d'un sujet nécessitant un tel traitement. Le procédé consiste en l'administration dans les bronches du sujet d'une uridine phosphate telle qu'une uridine 5'Îtriphosphate (UTP) ou P1,P4-di(uridine-5Î)tétraphosphate (U2P4), un analogue d'UTP ou tout autre analogue, en quantité suffisante pour améliorer le coefficient de clearance mucociliaire et/ou l'expectoration d'un fluide retenu dans les bronches, les bronchioles et les petites voies aériennes terminales. Les composés de l'invention sont administrables en inhalation par aérosol, sous forme de suspension liquide (y compris des gouttes ou un nébuliseur nasal), sous forme orale (liquide ou pilule), par injection, par instillation peropératoire ou sous forme de suppositoire.
Boucher Richard C. Jr.
Jacobus Karla M.
Rideout Janet L.
Shaffer Christy L.
Gowling Lafleur Henderson Llp
Inspire Pharmaceuticals Inc.
The University Of North Carolina At Chapel Hill
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