Method of treating cancer by restoration of pp32 function

Details Method of treating cancer by restoration of pp32 function Method of treating cancer by restoration of pp32 function

A - Human Necessities

61

K

A61K 48/00 (2006.01) A61K 31/00 (2006.01) C07K 14/47 (2006.01) C12N 15/63 (2006.01) C12Q 1/42 (2006.01) G01N 33/50 (2006.01) G01N 33/567 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2361838

Methods to treat existing cancer or prevent cancer formation by restoration of pp32 function in cells lacking normal pp32 activity or expression are provided. The methods provide for restoration of pp32 either through transfection of cells with DNA expressing normal pp32, administration of an inducer of pp32 activity and/or inhibition of a nuclear phosphatase that is inhibited by pp32.

La présente invention concerne le traitement ou la prévention de cancer par restauration de la fonction pp32 de cellules dépourvues d'activité ou d'expression pp32 normale. Le procédé assure cette restauration de pp32, par transfection des cellules avec de l'ADN exprimant la pp32 normale, par administration d'un inducteur de l'activité pp32, et/ou inhibition d'une phosphatase nucléaire inhibée par pp32.

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