Method of treating cancer using dithiocarbamate derivatives

Details Method of treating cancer using dithiocarbamate derivatives Method of treating cancer using dithiocarbamate derivatives

A - Human Necessities

61

K

A61K 31/27 (2006.01)

Patent

CA 2424761

Dithiocarbamate, particularly tetraethylthiuram disulfide, and thiocarbamate anions strongly inhibit the growth of cancer cells of a variety of cell types. Such inhibitory effect is enhanced by heavy metal ions such as copper ions, cytokines and ceruloplasmin. A method is presented for using tetraethylthiuram disulfide to reduce tumor growth, and to potentiate the effect of other anticancer agents.

Des anions de dithiocarbamate, en particulier de disulfure de tétraéthylthiurame, et de thiocarbamate inhibent puissamment la croissance de cellules cancéreuses d'une variété de types de cellules. Cet effet inhibiteur est accru par des ions métal lourds tels que des ions de cuivre, des cytokines et la céruloplasmine. Une méthode est présentée pour l'utilisation du disulfure de tétraéthylthiurame afin de réduire la croissance tumorale et de potentialiser l'effet d'autres agents anticancéreux.

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