Method of treating cancer using tetraethyl thiuram disulfide

A - Human Necessities – 61 – K

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A61K 31/145 (2006.01) A61K 31/325 (2006.01) A61K 33/04 (2006.01) A61K 33/24 (2006.01) A61K 33/26 (2006.01) A61K 33/30 (2006.01) A61K 33/32 (2006.01) A61K 33/34 (2006.01) A61K 33/36 (2006.01) A61K 33/38 (2006.01) A61K 38/20 (2006.01) A61K 38/21 (2006.01) A61K 38/57 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2384059

Dithiocarbamate, particularly tetraethylthiuram disulfide strongly inhibits the growth of cancer cells of a variety of cell types. Such inhibitory effect is enhanced by heavy metal ions such as copper ions, cytokines and ceruloplasmin. A method is presented for using tetraethylthiuram disulfide to reduce tumor growth, and to potentiate the effect of other anticancer agents.

Le dithiocarbamate, notamment le disulfure de tétraéthylthiurame, inhibe fortement la croissance des cellules cancéreuses d'une variété de types de cellules. Un tel effet inhibiteur est amélioré par des ions de métaux lourds, tels que les ions cuivre, des cytokines et la céruloplasmine. La présente invention concerne un procédé pour utiliser du disulfure de tétraéthylthiurame, afin de réduire la croissance tumorale et de potentialiser l'effet d'autres agents anticancéreux.

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