A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61P 25/00 (2006.01) A61P 35/00 (2006.01) C07K 14/71 (2006.01) C07K 16/22 (2006.01) C12N 15/11 (2006.01)
Patent
CA 2401604
A method of treating or preventing cancer by administering to a mammal a therapeutically effective amount of at least one anti-neurotrophin agent is described. The anti-neurotrophin agent is preferably an anti-neurotrophin antibody, an antisense molecule directed to a neurotrophin, a small organic molecule which binds a neurotrophin, or a dominant-negative mutation of a trk receptor that binds a neurotrophin. This method is particularly preferred for the treatment of prostate or pancreatic cancer. The anti-neurotrophic agents neutralize NGF, BDNF, NT-3, NT-4/5, NT-6 or NT-7 and include humanized antibodies as well as fragments thereof.
L'invention concerne une méthode de traitement ou de prévention du cancer, consistant à administrer à un mammifère une quantité efficace d'un point de vue thérapeutique d'au moins un agent anti-neurotrophique. L'agent anti-neurotrophique est, de préférence, un anticorps anti-neurotrophique, une molécule antisens dirigée contre une neurotrophine, une petite molécule organique liée à une neurotrophine, ou une mutation dominante négative d'un récepteur trk lié à une neurotrophine. Cette méthode est utilisée, en particulier, dans le traitement du cancer de la prostate ou du pancréas. Les agents anti-neurotrophiques neutralisent NGF, BDNF, NT-3, NT-4/5, NT-6 ou NT-7, et comprennent des anticorps humanisés ainsi que des fragments de ceux-ci.
Buchkovich Karen J.
Dionne Craig A.
Miknyoczki Sheila J.
Ruggeri Bruce A.
Cephalon Inc.
Goudreau Gage Dubuc
LandOfFree
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