Method of treating cancers with saha and pemetrexed

Details Method of treating cancers with saha and pemetrexed Method of treating cancers with saha and pemetrexed

A - Human Necessities

61

K

A61K 31/517 (2006.01) A61K 31/519 (2006.01) A61K 31/52 (2006.01)

Patent

CA 2636596

The present invention relates to a method of treating cancer in a subject in need thereof, by administering to a subject in need thereof a first amount of a histone deacetylase (HDAC) inhibitor or a pharmaceutically acceptable salt or hydrate thereof, and a second amount of an anti-cancer agent. The HDAC inhibitor and the anti-cancer agent may be administered to comprise therapeutically effective amounts. In various aspects, the effect of the HDAC inhibitor and the anti-cancer agent may be additive or synergistic.

La présente invention concerne un procédé de traitement anticancéreux d~un patient par administration d~une première quantité d~inhibiteur de la histone désacétylase (HDAC) ou d~un sel ou hydrate dudit inhibiteur pharmaceutiquement acceptable, puis d~une seconde quantité d~un agent anticancéreux. L~inhibiteur de HDAC et l~agent anticancéreux peuvent être administrés en des quantités efficaces sur le plan thérapeutique. Sous divers aspects, les effets de l~inhibiteur de HDAC et de l~agent anticancéreux peuvent se combiner de manière additive ou synergique.

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