Method of treating cerebral ischemia

Details Method of treating cerebral ischemia Method of treating cerebral ischemia

C - Chemistry, Metallurgy

07

K

167/103.8

C07K 14/665 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1252718

Abstract A composition suitable for use in the treatment of cerebral ischemia in live mammals comprising a therapeutically effective amount of an opioid peptide and a physiologically acceptable carrier. Preferably, the opioid peptide has the amino acid sequence TRY-GLY-GLY-PHE-LEU-ARG-AA8-AA9- AA10-(AA11)w, wherein AA8 is TRY, ILU, LEU or LYS, AA9 is ARG or PRO, AA10 is PRO or LYS, AA11 is LYS, LYS-LEU or LYS-LEU-LYS, w is 0 or 1, and the opioid peptide is in acid or amidated form. The administration of the opioid peptide is useful in prolonging survival.

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