A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/70 (2006.01) A61K 31/737 (2006.01)
Patent
CA 2285950
A method of treating a mammalian patient suffering from a chronic progressive vascular scarring disease (CPVSD), particularly arteriosclerotic diseases such as atherosclerosis, to halt or at least slow substantially the progress of the disease and cause resolution and/or diminution of already-formed scarring and lesions. The method consists of the administration to the patient of a pharmaceutical composition containing an effective amount of pentosan polysulfate (PPS) or a pharmaceutically acceptable salt thereof. The oral route of administration is preferred, with the total daily dosage of PPS or PPS salt ranging from about 5 to about 30 mg/kg of patient body weight, or about 350 to about 2,000 mg per day in adult human patients.
Méthode de traitement d'un mammifère souffrant de maladie vasculaire évolutive chronique accompagnée de cicatrices, en particulier de maladie artériosclérotique telle que l'athérosclérose, permettant de stopper ou au moins de ralentir considérablement l'évolution de la maladie et provoquer la résorption et/ou la diminution des cicatrices et lésions déjà formées. Ladite méthode consiste à administrer au patient une composition pharmaceutique contenant une quantité efficace de polysulfate de pentosan (PPS) ou un sel pharmaceutiquement acceptable de ladite substance. Le mode d'administration préféré est la voie orale, la dose quotidienne totale de PPS ou de sel de PPS allant d'environ 5 à environ 30 mg/kg de poids corporel du patient, ou d'environ 350 à environ 2.000 mg par jour pour les patients humains adultes.
Striker Gary E.
Striker Liliane J.
Department O. F. Health & Human Services The United States Of America Represented By The Secretary
Sim & Mcburney
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