Method of treating colonic adenomas

Details Method of treating colonic adenomas Method of treating colonic adenomas

A - Human Necessities

61

K

A61K 31/40 (2006.01) A61K 31/00 (2006.01) A61K 31/12 (2006.01) A61K 31/18 (2006.01) A61K 31/19 (2006.01) A61K 31/192 (2006.01) A61K 31/195 (2006.01) A61K 31/196 (2006.01) A61K 31/275 (2006.01) A61K 31/34 (2006.01) A61K 31/365 (2006.01) A61K 31/38 (2006.01) A61K 31/405 (2006.01) A61K 31/407 (2006.01) A61K 31/54 (2006.01) A61K 31/5415 (2006.01)

Patent

CA 2227238

This invention is directed to a method of retarding or preventing the transformation of a colonic adenoma to a colonic adenocarcinoma comprising the administration to a patient with FAP or a patient with one or more of said adenomas a non-toxic therapeutically effective amount of NSAID, said amount effective to inhibit the PGHS-2 in said adenoma. The preferred method comprises the administration of a specific PGHS-2 inhibiting agent as defined herein.

L'invention se rapporte à un procédé qui permet de retarder ou d'empêcher la transformation d'un adénome colique en adénocarcinome colique, et qui consiste à administrer au patient atteint de polypose rectocolique ou au patient atteint d'un ou de plusieurs des adénomes sus-mentionnés une quantité non toxique thérapeutiquement efficace d'agents anti-inflammatoires non stéroïdiens, ladite quantité efficace ayant pour effet d'inhiber l'isozyme PGHS-2 de la prostaglandine H2 synthétase dans le type d'adénome considéré. Le mode de réalisation préféré consiste à administrer un agent inhibiteur de PGHS-2 spécifique tel que défini dans l'invention.

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