Method of treating conditions with estrogen agonists

Details Method of treating conditions with estrogen agonists Method of treating conditions with estrogen agonists

A - Human Necessities

61

K

A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/4439 (2006.01) A61K 31/445 (2006.01) A61K 31/4453 (2006.01) A61K 31/4725 (2006.01)

Patent

CA 2198562

Pharmaceutical compositions that comprise compounds of this formula (see fig. I) (wherein A is CH2 or NR; R is H or alkyl; B, D and E are each CH or N; Y is a cyclic group such as phenyl; Z1 is a divalent group such as -O-CH2CH2-; G is an optionally substituted amino such as piperidino or pyrrolidino; and e is 0, 1 or 2) are useful for treating or preventing Alzheimer's disease, premenstrual syndrome, perimenopausal syndrome, a deficiency of thrombomodulin, uterine fibrosis, excessive myeloproxidase activity, excessive thrombin, autoimmune disease, reperfusion damage of ischemic myocardium and insufficient testosterone.

Compositions pharmaceutiques renfermant des composés de formule I (voir fig. I) ¢où A est CH2 ou NR; R est H ou un alkyle; B, D et E sont chacun CH ou N; Y est un groupe cyclique comme le phényle; Z1 est un groupe divalent comme -OCH2CH2; G est un groupe amino avec substitution facultative, comme un pipéridino ou un pyrrolidino; e est 0, 1 ou 2!, utiles pour le traitement ou la prévention de la maladie d'Alzheimer, du syndrome prémenstruel, du syndrome de la périménopause, de la carence en thrombomoduline, de la fibrose utérine, de l'activité excessive de la myéloproxidase, d'un taux excessif de thrombine, de maladies auto-immunes, lésions consécutives à la perfusion au niveau du myocarde en cardiopathie ischémique, et d'un taux insuffisant de testostérone.

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