C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 333/68 (2006.01) A61K 31/381 (2006.01) A61P 3/10 (2006.01) C07D 333/78 (2006.01)
Patent
CA 2498399
The present invention addresses the use of substituted thiophene derivatives, as well as compositions containing such compounds for treating type 2 diabetes mellitus. The compounds in the present invention are glucagon antagonists. The compounds block the action of glucagon at its receptor and thereby decrease the levels of plasma glucose providing a treatment of diabetes.
L'invention concerne l'utilisation de dérivés de thiophène substitués, ainsi que des compositions contenant ces composés qui permettent de traiter le diabète de type 2. Les composés de l'invention sont des antagonistes du glucagon. Lesdits composés bloquent l'action du glucagon au niveau de son récepteur et font ainsi baisser les niveaux de glycémie veineuse, ce qui constitue un traitement contre le diabète.
Campbell Elizabeth Louise
Duffy Joseph
Konteatis Zenon
Liang Rui
Qureshi Sajjad A.
Gowling Lafleur Henderson Llp
Merck & Co. Inc.
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