Method of treating disease involving myelin and/or axonal loss

A - Human Necessities – 61 – K

Patent

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A61K 31/445 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2696310

Disclosed is a method of treating a disease involving myelin and/or axonal loss, such as a demyelinating disease, in a mammal comprising administering a compound of formula I, in which R1-R11 and n are defined herein. Also disclosed are methods of using a compound of formula 1 to treat neurodegeneration associated with inflammation and to reduce myelin and/or axonal loss.

La présente invention concerne un procédé de traitement de maladies impliquant la perte de myéline et/ou perte axonale telle que la maladie démyélisante chez les mammifères, et qui comprend l'administration d'un composé de formule I dans lequel R1-R11 et n sont définis ici. L'invention concerne également des procédés d'utilisation d'un composé de formula 1 destiné à traiter la neurodégénérescence associée à l'inflammation et à réduire la perte de myéline et/ou la parte axonale.

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