C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/00 (2006.01) A61K 31/47 (2006.01) A61K 31/472 (2006.01) A61K 31/496 (2006.01) A61K 31/553 (2006.01) A61K 31/7076 (2006.01) A61K 31/711 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2297410
It is shown here that hedgehog proteins or mimicking agents possess novel activities beyond phenotype specification. Using cultures derived from the embryonic day 14.5 (E14.5) rat ventral mesencephalon, we show that hedgehog or mimicking agents are also trophic for dopaminergic neurons. Interestingly, hedgehog or mimicking agents not only promote dopaminergic neuron survival, but also promote the survival of midbrain GABA-immunoreactive (GABA-ir) neurons.
Selon cette invention, les protéines "en hérisson" ou des agents de mimétisme ont de nouvelles activités qui dépassent la spécification phénotypique. En utilisant les cultures dérivées du mésencéphale ventral d'un embryon du rat de 14,5 jours (E14,5), on a demontré que les protéines "en hérisson" sont également trophiques vis-à-vis des neurones dopaminergiques. Il est intéressant de noter que ces protéines "en hérisson" favorisent non seulement la survie des neurones dopaminergiques mais aussi celle des neurones immunoréactifs au GABA (GABA-ir) du mésencéphale.
Mahanthappa Nagesh K.
Miao Ningning
Pang Kevin
Wang Monica
Borden Ladner Gervais Llp
Curis Inc.
Ontogeny Inc.
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