C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/71 (2006.01) A61K 31/00 (2006.01) A61K 45/06 (2006.01)
Patent
CA 2621047
Methods of reducing or treating angiogenesis and/or inflammation associated with eye injury in a subject in need thereof, comprising locally administering a first agent vascular endothelial growth factor (VEGF) antagonist are provided. Use of a VEGF antagonist for treating corneal injury and related neovascularization and/or inflammation are described. The methods are useful for inhibiting or ameliorating eye injury, particularly acute or subacute corneal injury and feature local administration (for example, subconjunctival injection or eye drops).
L'invention concerne des méthodes visant à réduire ou à traiter chez un sujet nécessitant un tel traitement l'angiogenèse et/ou l'inflammation associées à une lésion oculaire. Les méthodes comprennent l'administration locale d'un premier agent antagoniste du facteur de croissance de l'endothélium vasculaire (VEGF). L'invention concerne l'utilisation d'un antagoniste du VEGF pour traiter une lésion cornéenne et la néovascularisation et/ou l'inflammation associées. Ces méthodes permettent d'inhiber ou d'améliorer la lésion oculaire, en particulier une lésion aiguë ou subaiguë de la cornée par une administration locale (par exemple, injection sous-conjonctivale ou gouttes oculaires).
Cao Jingtai
Wiegand Stanley J.
Blake Cassels & Graydon Llp
Regeneron Pharmaceuticals Inc.
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