Method of treating gram-negative bacterial infection by...

Details Method of treating gram-negative bacterial infection by... Method of treating gram-negative bacterial infection by...

A - Human Necessities

61

K

A61K 38/17 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2172245

The present invention relates to methods and compositions for treating gram- negative bacterial infections, using BPI protein products. Co-treatment, or concurrent administration, of BPI protein product with an antibiotic in treatment of gram-negative bacterial infections improves the therapeutic effectiveness of the antibiotic, including increasing antibiotic susceptibility of gram-negative bacteria and reversing resistance of the bacteria to antibiotics.

L'invention concerne des procédés ainsi que des compositions de traitement d'infections bactériennes Gram négatif, à l'aide de produits protéiques (BPI). Le traitement conjoint ou l'administration simultanée d'un produit protéique (BPI) avec un antibiotique dans le traitement d'infections bactériennes Gram négatif améliore l'efficacité thérapeutique de l'antibiotique, y compris l'augmentation de la sensibilité à l'antibiotique de bactéries gramme-négatif ainsi que l'inversion de la résistance des bactéries aux antibiotiques.

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