A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 8/46 (2006.01) A61K 8/49 (2006.01) A61Q 7/00 (2006.01)
Patent
CA 2374260
A method of treating hair loss comprising administering a composition comprising a cardiac-sparing compound characterized by structure (I) and pharmaceutically acceptable salts, hydrates, and biohydrolyzable amides, esters, and imides thereof, wherein: R1 is -(CH2)n(CHNR7R8)mC(O)R9; n is an integer from 1 to 3; m is an integer from 0 to 1; R3 and R5 are each, independently, selected from the group consisting of chlorine, bromine, iodine, and -CH3, R7 and R8 are each, independently, selected from the group consisting of hydrogen and C1-C4 alkyl; R9 is selected from the group consisting of hydroxy, C1-C4 alkoxy, and -NR7R8; R31 is selected from the group consisting of hydrogen, chlorine, bromine, iodine, C1-C4 alkyl, C4-C6 cycloalkyl, C1-C4 haloalkyl, C4-C6 halocycloalkyl, and -CH(R10)Ar; Ar is selected from the group consisting of 5-hydroxypyrid-2-yl, 6-hydroxypyrid-3- yl, 6-hydroxypyridazin-3-yl, 6-methoxypyridazin-3-yl N-oxide, and 6- hydroxypyridazin-3-yl N-oxide; R10 is selected from the group consisting of hydrogen and C1-C4 alkyl; and R41 is selected from the group consisting of hydroxy and C1-C4 alkoxy.
L'invention concerne une méthode de traitement de la perte des cheveux consistant à administrer une composition contenant un composé ménageant le coeur caractérisé par la structure (I) ainsi que leurs sels, hydrates acceptables sur le plan pharmaceutique et leurs amides, esters et imides biohydrolysables, structure dans laquelle R¿1? représente -(CH¿2?)¿n?(CHNR¿7?R¿8?)¿m?C(O)R¿9?; n représente un nombre entier de 1 à 3; m représente un nombre entier de 0 à 1; R¿3? et R¿5? sont sélectionnés chacun indépendamment dans le groupe contenant le chlore, le brome, l'iode et -CH¿3?; R¿7? et R¿8? sont choisis chacun indépendamment dans le groupe contenant hydrogène et alkyle C¿1?-C¿4?; R¿9? est choisi dans le groupe contenant hydroxy, alcoxy C¿1?-C¿4? et -NR¿7?R¿8?; R¿31? est choisi dans le groupe contenant hydrogène, chlore, brome, iode, alkyle C¿1?-C¿4?, cycloalkyle C¿4?-C¿6?, haloalkyle C¿1?-C¿4?, halocycloalkyle C¿4?-C¿6? et -CH(R¿10?)Ar; Ar est choisi dans le groupe contenant 5-hydroxypyrid-2-yle, 6-hydroxypyrid-3-yle, 6-hydroxypyridazin-3-yle, 6-méthoxypyrydazin-3-yle N-oxyde et 6-hydroxypyridazin-3-yle N-oxyde; R¿10? est choisi dans le groupe contenant hydrogène et alkyle C¿1?-C¿4?; et R¿41? est choisi dans le groupe contenant hydroxy et alcoxy C¿1?-C¿4?.
Youngquist Robert Scott
Zhang Lixin Lilly
Smart & Biggar
The University Of Texas Southwestern Medical Center
LandOfFree
Method of treating hair loss using sulfonyl thyromimetic... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of treating hair loss using sulfonyl thyromimetic..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treating hair loss using sulfonyl thyromimetic... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1407886