Method of treating hematologic tumors and cancers

Details Method of treating hematologic tumors and cancers Method of treating hematologic tumors and cancers

A - Human Necessities

61

K

A61K 31/352 (2006.01) A61K 31/135 (2006.01) A61K 31/337 (2006.01) A61K 31/365 (2006.01) A61K 31/381 (2006.01) A61K 31/4184 (2006.01) A61K 31/427 (2006.01) A61K 31/473 (2006.01) A61K 31/4745 (2006.01) A61K 31/475 (2006.01) A61K 31/5377 (2006.01) A61K 31/704 (2006.01) A61K 31/7048 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01)

Patent

CA 2428425

Multiple myeloma and other hematologic tumors and/or malignancies can be treated by administration of a G1 and/or S phase drug, which is preferably .beta.-lapachone, or a derivative or analog thereof, combined with a G2/M phase drug such as taxane derivative, which is advantageously paclitaxel. This combination of the G1 and/or S phase drug with the G2/M phase drug results in an unexpectedly greater than additive (i.e., synergistic) apoptosis in multiple myeloma cells. The invention includes methods of treating multiple myeloma by administering the combination of the G1 and/or S phase drug and the G2/M phase drug, pharmaceutical compositions comprising the combination of drugs used in these methods, as well as pharmaceutical kits.

L'invention concerne des myélomes multiples et d'autres tumeurs et/ou malignités hématologiques pouvant être traités par administration d'un médicament à phase G1 et/ou S, qui est, de préférence, du .beta.-lapachone, ou un dérivé ou analogue de celui-ci, combiné à un médicament à phase G2/M tel qu'un dérivé de taxane, de préférence du paclitaxel. Cette combinaison de médicament à phase G1 et/ou S avec un médicament à phase G2/M produit un effet supérieur inattendu, à l'effet apoptotique additif (à savoir, synergique) dans les cellules myélomes multiples. L'invention concerne également des procédés de traitement des myélomes multiples par administration d'une combinaison de médicament à phase G1 et/ou S et de médicament à phase G2/M, des compositions pharmaceutiques comprenant la combinaison de médicaments utilisée dans ces procédés, ainsi que des trousses pharmaceutiques.

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