Method of treating hepatitis delta viral infection

A - Human Necessities – 61 – K

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Details

A61K 31/7072 (2006.01) A61P 31/14 (2006.01)

Patent

CA 2405502

A method for the treatment for hepatitis delta infection in a host, that includes administering an effective amount of a nucleoside or a nucleoside analog or a prodrug or pharmaceutically acceptable salt thereof that suppresses the expression of the hepatitis B surface or preS1 antigen in the host 100-fold or more relative to pretreatment values in vivo; or to not move than 1 microgram per milliliter in vivo. In a preferred embodiment, the nucleoside is L-FMAU, or a pharmaceutically acceptable salt or prodrug thereof.

L'invention concerne un procédé de traitement d'une infection par le virus de l'hépatite D chez un hôte, consistant à administrer une quantité efficace d'un nucléoside ou d'un analogue de nucléoside, ou un promédicament ou un sel de celui-ci pharmaceutiquement acceptable qui supprime de 100 fois ou plus, ou d'un microgramme ou moins par millilitre, l'expression d'un antigène de surface de l'hépatite B ou d'un antigène preS1 chez l'hôte par rapport au valeurs de prétraitement in vivo. Selon un mode de réalisation, le nucléoside est L-FMAU, ou un sel pharmaceutiquement acceptable, ou un pro-médicament de celui-ci.

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