Method of treating hepatitis virus infection with a...

A - Human Necessities – 61 – K

Patent

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A61K 38/21 (2006.01) A61P 31/14 (2006.01)

Patent

CA 2460690

The present invention provides methods of treating hepatitis virus infection. The methods generally involve administering a composition comprising an antiviral agent in a dosing regimen that achieves a multiphasic serum concentration profile of the antiviral agent. The dosing regiment includes dosing events that are less frequent than with currently available hepatitis therapies. The multiphasic antiviral agent serum concentration profile that is achieved using the methods of the invention effects an initial rapid drop in viral titer, followed by a further decrease in viral titer over time, to achieve a sustained viral response.

L'invention se rapporte à des procédés de traitement de l'infection par le virus de l'hépatite. Ces procédés consistent généralement à administrer une composition contenant un agent antiviral dans un schéma posologique de dosage qui permet d'obtenir un profil de concentration de sérum multiphasique de l'agent antiviral. Ce schéma posologique contient des événements de dosage qui sont moins fréquents que dans les thérapies contre l'hépatite couramment utilisées. Ce profil de concentration de sérum d'agent antiviral multiphasique qui est obtenu au moyen des procédés selon l'invention entraîne une baisse initiale rapide dans un titre viral, suivie d'une autre baisse dans un titre viral au bout d'un certain temps, avant d'obtenir une réponse virale durable.

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