Method of treating inflammation and compositions therefor

Details Method of treating inflammation and compositions therefor Method of treating inflammation and compositions therefor

A - Human Necessities

61

K

A61K 38/55 (2006.01) C07K 14/81 (2006.01)

Patent

CA 2214988

Compositions and methods for treating inflammatory cell infiltration in a tissue of a mammalian subject are provided. The method involves administering a therapeutically effective amount of SERP-1, SERP-1 analog or biologically active fragment thereof admixed with a pharmaceutically acceptable carrier to a subject in need of such treatment. Biologically active SERP-1 analogs are also provided. The compositions and methods of the present invention are useful for treating numerous inflammatory based diseases and injuries.

Cette invention se reporte à des compositions et à des procédés pour traiter l'infiltration de cellules inflammatoires dans les tissus d'un mammifère. Ce procédé consiste à administrer à un sujet nécessitant un tel traitement une quantité thérapeutiquement efficace de l'agent SERP-1, d'un analogue de SERP-1 ou d'un fragment biologiquement actif de ceux-ci, mélangés à un excipient pharmaceutiquement acceptable. Des analogues de SERP-1 actifs sur le plan biologique sont également présentés. Ces compositions et ces procédés servent à traiter de nombreuses maladies et lésions de nature inflammatoire.

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