A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 31/20 (2006.01) A61K 31/445 (2006.01) A61K 31/52 (2006.01) A61K 38/08 (2006.01) A61K 38/12 (2006.01) C07K 16/24 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2177570
The present invention provides a method of treating or preventing in a subject an intestinal disorder caused by an elevated level of TNF in the lumen of the intestine of the subject. The method involves administering to the subject an agent which reduces the action of the intralumenal TNF or reduces the production or accumulation of intralumenal TNF. The agent may be any of a number of known anti-TNF agents, however, it is preferred that the agent is an anti-TNF antibody. It is also preferred that the agent is administered directly into the intestine.
La présente invention concerne une méthode popur traiter ou prévenir chez un sujet les troubles intestinaux provoqués par un niveau élevé de facteur de nécrose des tumeurs (FNT) à l'intérieur de l'intestin. Cette méthode fait appel à l'administration au sujet d'un agent qui diminue l'action du FNT endoluminal ou limite la production et l'accumulation de FNT endoluminal. Cet agent peut être l'un des nombreux agents anti-FNT connus. Toutefois, il est préférable que l'agent soit un anticorps anti-FNT. On préfère également que l'agent soit administré directement dans l'intestin.
Jackson Graham Douglas Fischer
Swabey Ogilvy Renault
Unisearch Limited
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