Method of treating lower urinary tract disorders

Details Method of treating lower urinary tract disorders Method of treating lower urinary tract disorders

A - Human Necessities

61

K

A61K 31/551 (2006.01) A61K 31/135 (2006.01) A61K 31/519 (2006.01) A61K 31/535 (2006.01)

Patent

CA 2519379

The invention relates to a method of treating at least one symptom of a lower urinary tract disorder in a subject in need of treatment wherein the symptom is selected from the group consisting of urinary frequency, urinary urgency, urinary urge incontinence, nocturia and enuresis. The method comprises administering to a subject in need of treatment a therapeutically effective amount of a compound that has 5-HT3 receptor antagonist activity and NorAdrenaline Reuptake Inhibitor (NARI) activity. The invention further relates to a method of treating at least one symptom of a lower urinary tract disorder in a subject in need of treatment wherein the symptom is selected from the group consisting of urinary frequency, urinary urgency, urinary urge incontinence, nocturia and enuresis, comprising coadministering to said subject a first amount of a 5~HT3 antagonist and a second amount of a NARI, wherein the first and second amounts together comprise a therapeutically effective amount or are each present in a therapeutically effective amount.

L'invention porte sur une méthode de traitement chez un patient le nécessitant, de l'un au moins des symptômes de troubles des voies urinaires inférieures sélectionnés parmi: la fréquence urinaire, l'urgence urinaire, l'incontinence urinaire d'urgence, la nycturie et l'énurésie consistant à administrer au patient une quantité à efficacité thérapeutique d'un composé présentant l'activité antagoniste d'un récepteur 5-TH¿3? et l'activité du NARI (inhibiteur de recaptage de la NorAdrénaline). L'invention porte en outre sur une méthode de traitement chez un patient le nécessitant, de l'un au moins des symptômes de troubles des voies urinaires inférieures sélectionnés parmi: la fréquence urinaire, l'urgence urinaire, l'incontinence urinaire d'urgence, la nycturie et l'énurésie. consistant à co-administrer au patient une première quantité de 5-TH¿3? et une deuxième quantité de NARI, les deux quantités formant une quantité à efficacité thérapeutique ou étant présentes dans une quantité à efficacité thérapeutique.

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