Method of treating of demyelinating diseases or conditions

Details Method of treating of demyelinating diseases or conditions Method of treating of demyelinating diseases or conditions

A - Human Necessities

61

K

A61K 31/4439 (2006.01) A61P 13/10 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2438712

N-(Pyridinyl)-1H-indol-1-amines of formula I provide a unique combination of blocking properties for both the potassium and sodium channels. These compounds are useful for the treatment of Demyelinating Diseases and Conditions such as Multiple Sclerosis, Spinal Cord Injury, Traumatic Brain Injury and Stroke. The compounds are also useful for Stroke Rehabilitation, the treatment of Bladder Irritation and Dysfunction, and the treatment of Neuropathic Pain and Chemokine-Induced Pain.

Les N-(Pyridinyl)-1H-indol-1-amines représentées par la formule générale (I) permettent d'obtenir une combinaison unique de propriétés bloquantes pour les canaux potassiques et sodiques. Ces composés sont utiles pour le traitement de pathologies et de troubles liés à la démyélinisation, tels que la sclérose en plaques, le traumatisme médullaire, le traumatisme cérébral et l'accident vasculaire cérébral. Ces composés sont également utiles pour la réhabilitation à la suite d'un AVC, pour le traitement de l'irritation et de la dysfonction vésicale et pour le traitement de la douleur neuropathique et de la douleur induite par les chimiokines.

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