Method of treating or inhibiting neutropenia

Details Method of treating or inhibiting neutropenia Method of treating or inhibiting neutropenia

A - Human Necessities

61

K

A61K 31/505 (2006.01) A61K 31/519 (2006.01) A61K 31/5377 (2006.01)

Patent

CA 2273288

The invention is a method of treating or inhibiting neutropenia, or accelerating neutrophil recovery in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound, or a medicament containing said compound having formula (I) wherein R1 and R2 are each, independently selected from the group consisting of hydrogen, alkyl of 1- 6 carbon atoms, optionally substituted benzoyl, (a), (b), (c), (d), (e), (f), and -(CH2)n-R; or R1 and R2 are methylene groups which are taken together to form a 4-7 membered saturated heterocyclic ring; R is hydroxy, 4-morpholinyl, 1H-imidazol-1-yl, -CH(alkoxy of 1-6 carbon atoms)2, .alpha.-hydroxybenzyl, or optionally substituted phenyl; R3 is hydrogen or alkyl; R4 is hydrogen, halogen, alkyl, alkoxy, or trifluoromethyl; R5 is hydrogen or alkyl; and n = 1- 3, or a pharmaceutically acceptable salt thereof.

Méthode pour traiter ou inhiber la neutropénie, ou pour accélérer la récupération de neutrophiles chez le mammifère présentant une insuffisance de ces derniers. Cette méthode consiste à administrer à ce mammifère une quantité efficace d'un composé ou d'un médicament contenant le composé de la formule (I) dans laquelle R¿1? et R¿2? sont chacun sélectionnés indépendamment dans un groupe constitué de l'hydrogène, d'un alkyl comprenant entre 1 et 6 atomes de carbone, de benzoyle éventuellement substitué, (a), (b), (c), (d), (e), (f) et -(CH¿2?)¿n?-R ou R¿1? et R¿2? sont des groupes méthylène réunis pour former un noyau hétérocyclique saturé comprenant 4 à 7 chaînons; R est hydroxy, 4-morpholinyle, 1H-imidazol-1-yl, -CH(alkoxy à 1-6 atomes de carbone)¿2?, .alpha.-hydroxybenzyle ou phényle éventuellement substitué; R¿3? est l'hydrogène ou l'alkyle; R¿4? est l'hydrogène, halogène, alkyle, alkoxy ou trifluorométhyle; R¿5? est l'hydrogène ou l'alkyle; et n=1-3, ou un sel pharmaceutiquement acceptable de ce composé.

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