Method of treating or preventing pathologic effects of acute...

A - Human Necessities – 61 – K

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A61K 31/19 (2006.01) A61K 31/40 (2006.01) A61K 31/407 (2006.01)

Patent

CA 2568134

One aspect of the present invention relates to a method of treating or preventing pathologic sequelae of acute hyperglycemia and/or increased fatty acid flux in a subject. This method involves administering an ROS inhibitor to the subject. In addition, methods of promoting neovascularization, inhibiting oxidation or excessive release of free fatty acids, and identifying compounds suitable for treatment or prevention of ROS-mediated injury are also disclosed.

Un mode de réalisation de l'invention concerne une méthode de traitement ou de prévention des séquelles pathologiques de l'hyperglycémie aiguë et/ou des flux accrus d'acides gras chez un sujet. Cette méthode consiste à administrer un inhibiteur de ROS au sujet. De plus, l'invention concerne des procédés permettant de favoriser la néovascularisation, d'inhiber l'oxydation ou une libération excessive d'acides gras libres et d'identifier des composés conçus pour le traitement ou la prévention de blessures induites par ROS.

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