Method of treating or preventing tissue deterioration,...

A - Human Necessities – 61 – K

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A61K 38/08 (2006.01)

Patent

CA 2593201

A method of treatment for treating, preventing, inhibiting or reducing tissue deterioration, injury or damage due to a neuro-, muscular- or neuro-muscular- degenerative disease, or for restoring tissue adversely affected by said disease, in a subject, includes administering to a subject in need of such treatment an effective amount of a composition including a peptide agent including amino acid sequence LKKTET or LKKTNT, a conservative variant thereof, or a peptide agent that stimulates production of an LKKTET or LKKTNT peptide, or a conservative variant thereof, in the tissue.

L'invention concerne une méthode de traitement permettant de traiter, de prévenir, d'inhiber ou de réduire une détérioration, une blessure ou un dommage tissulaire engendré par une maladie neuro-dégénérative, dégénérative musculaire ou dégénérative neuro-musculaire ou permettant de restaurer un tissu altéré par une telle maladie chez un sujet et consistant à administrer à celui-ci une quantité efficace d'une composition comprenant un agent peptidique renfermant une séquence d'acides aminés LKKTET ou LKKTNT, un variant conservatif de celui-ci ou un agent peptidique stimulant la production d'un peptide LKKTET ou LKKTNT ou un variant conservatif de celui-ci, dans le tissu.

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