Method of treating otitis media with uridine triphosphates...

A - Human Necessities – 61 – K

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Details

A61K 31/70 (2006.01) A61K 31/7068 (2006.01) A61K 31/7072 (2006.01) A61K 31/7076 (2006.01) A61K 31/7084 (2006.01) A61P 27/16 (2006.01) B65B 43/26 (2006.01) C07H 19/10 (2006.01) C07H 19/20 (2006.01) C07H 19/207 (2006.01)

Patent

CA 2246581

A method of promoting drainage of congested middle ear fluid in a subject in need of such treatment is disclosed. The method comprises administering to the middle ear of the subject a uridine triphosphate such as uridine 5'- triphosphate (UTP), an analog of UTP, or any other analog, in an amount effective to promote drainage of congested middle ear fluid by hydrating mucous secretions in the middle ear or by stimulating ciliary beat frequency in the middle ear or eustachian tube. The method is useful for treating patients afflicted with otitis media and other middle ear diseases, otitis externa, and inner ear diseases including Ménière's Disease. Pharmaceutical formulations and methods of making the same are also disclosed. Methods of administering the same would include any liquid suspension (including nasal drops or spray), oral, inhaled by nebulization, topical, injected or suppository form.

L'invention se rapporte à un procédé destiné à faciliter le drainage du fluide congestif de l'oreille moyenne chez un sujet nécessitant ce traitement. Ce procédé consiste à administrer à l'or eille moyenne du sujet un uridine-triphosphate tel que uridine 5 '-triphosphate (UTP), un analogue d'UTP ou tout autre analogue, dans une dose efficace afin de faciliter le drainage du fluide congestif de l'oreille moyenne, par hydratation des sécrétions muqueuses de l'oreille moyenne ou par stimulation de la fréquen ce de battement ciliaire de l'oreille moyenne ou de la trompe d'Eustache. Ce procédé est utile pour traiter des patients souffrant d'otite moyenne et d'autres pathologies de l'oreille moyenne, d'otite externe et de pathologies de l'oreille interne telle que la maladie de Ménière. L'invention se rapporte également à des formulations pharmaceutiques et à leurs procédés de fabrication, ainsi qu'aux procédés d'administration de ces formulations qui comprennent toute suspension liquide (y compris gouttes ou pulvérisations nasales), administrée par voie orale, locale inhalée par nébulisation, injectée ou sous forme de suppositoire.

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