A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 51/00 (2006.01) A61K 39/395 (2006.01) C07K 16/46 (2006.01) G01N 33/53 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2629453
The invention described herein is related to antibodies directed to the antigen TIM-1 and uses of such antibodies for the treatment of cancer (e.g., renal and ovarian cancer). In particular, there are provided fully human monoclonal antibodies directed to the antigen TIM-1. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR' s) and/or complementarity determining regions (CDR' s), specifically from FRl through FR4 or CDRl through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
La présente invention concerne des anticorps dirigés contre l'antigène TIM-1 et les utilisations de tels anticorps dans le traitement du cancer (tel que le cancer du rein et le cancer de l'ovaire). En particulier, l'invention concerne des anticorps monoclonaux entièrement humains dirigés contre l'antigène TIM-1. Cette invention concerne également des séquences polynucléotidiques isolées codant, et des séquences d'acides aminés comprenant, des molécules d'immunoglobuline à chaînes lourdes et légères, en particulier des séquences correspondant à des séquences à chaînes lourdes et légères contiguës couvrant les régions de cadre (FR) et/ou des régions déterminant la complémentarité (CDR), spécifiquement de FR1 à FR4 ou de CDR1 à CDR3. Cette invention concerne aussi des hybridomes ou autres lignées cellulaires exprimant de telles molécules d'immunoglobuline et lesdits anticorps monoclonaux.
Jeffers Michael E.
Larochelle William J.
Lichenstein Henri
Macdougall John
Mansfield Traci
Curagen Corporation
Ridout & Maybee Llp
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