Method of treating periodontitis and of reducing dentinal...

A - Human Necessities – 61 – K

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A61K 33/00 (2006.01) A61K 9/08 (2006.01) A61K 9/10 (2006.01) A61K 9/14 (2006.01) A61K 47/22 (2006.01) A61P 1/02 (2006.01)

Patent

CA 2643569

An improved method of treating periodontitis includes the steps of: creating a formulation containing a lanthanide-containing protease inhibitor; and applying the formulation to a periodontal area. The lanthanide may be cerium chloride, samarium chloride, lutetium chloride, cerium chloride heptahydrate, lutetium chloride hexahydrate, samarium chloride hexa- hydrate, gadolinium, gadolinium nitrate, gadolinium chloride, gadolinium chloride hexahydrate and gadolinium nitrate hexahydrate. The invention also provides an improved method of reducing dentinal sensitivity, including the steps of: creating a formulation containing at least one of gadolinium and a gadolinium-containing compound; and applying the formulation to a sensitive dentinal area. The formulation may be a paste, a solution or a powder.

L'invention concerne un procédé amélioré de traitement de la parodontite, comprenant les étapes consistant à : préparer une formulation contenant un inhibiteur de protéase contenant un lanthanide ; et appliquer la formulation sur une zone du parodonte. Le lanthanide peut être le chlorure de cérium, le chlorure de samarium, le chlorure de lutécium, le chlorure de cérium heptahydraté, le chlorure de lutécium hexahydraté, le chlorure de samarium hexahydraté, le gadolinium, le nitrate de gadolinium, le chlorure de gadolinium, le chlorure de gadolinium hexahydraté et le nitrate de gadolinium hexahydraté. L'invention concerne également un procédé amélioré de réduction de la sensibilité dentinaire, comprenant les étapes consistant à : préparer une formulation contenant l'un au moins parmi le gadolinium et un composé contenant du gadolinium ; et appliquer la formulation sur une zone sensible de la dentine. La formulation peut être une pâte, une solution ou une poudre.

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