Method of treating schizophrenia and/or glucoregulatory...

A - Human Necessities – 61 – K

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A61K 31/4439 (2006.01) A61P 3/10 (2006.01) A61P 25/18 (2006.01)

Patent

CA 2561162

The present invention provides methods of treating schizophrenia and/or glucoregulatory abnormalities in a patient in need thereof comprising administering to said patient a therapeutically effective amount of a compound of formula (I) wherein m is 0, 1 or 2; n is 0, 1 or 2; p is 0 or 1; each R is independently hydrogen, halogen, trifluoromethyl, C1-C6alkyl, C1-C6alkoxy, benzyloxy, hydroxy, nitro or amino; each R1 is independently hydrogen, C1- C6alkyl, C1-C6alkenyl, C1-C6alkanoyl, halogen, cyano, -C(O) C1-C6alkyl, -C1- C6alkyleneCN, -C1-C6alkyleneNR~R~ wherein R~ and R~ are each independently hydrogen or C1-C6alkyl, -C1-C6alkyleneOC(O)C1-C6alkyl, or -CH(OH)R4 wherein R4 is hydrogen or C1-C6alkyl; R2 is hydrogen, C1-C6alkyl optionally substituted with halogen, hydroxy or benzyloxy, C1-C6alkenyl, C1-C6alkynyl, -CO2C1- C6alkyl, or -R5-NR~R~ wherein R5 is C1-C6alkylene, C1-C6alkenylene or C1- C6alkynylene and R~ and R~ are each independently hydrogen, C1-C6alkyl or alternatively the group -NR~R~ as a whole is 1-pyrrolidinyl; and R3 is hydrogen, nitro, amino, halogen, C1-C6alkoxy, hydroxy or C1-C6alkyl or a pharmaceutically acceptable salt thereof.

Méthodes de traitement de la schizophrénie et / ou des anomalies de la glucorégulation chez un patient nécessitant un tel traitement, qui consistent à administrer à ce patient une quantité efficace sur le plan thérapeutique d'un composé de formule (I) dans laquelle m représente 0, 1 ou 2; n représente 0, 1 ou 2; p représente 0 ou 1; chaque R représente indépendamment hydrogène, halogène, trifluorométhyle, C1-C6alkyle, C1-C6alcoxy, benzyloxy, hydroxy, nitro ou amino; chaque R1 représente indépendamment hydrogène, C1-C6alkyle, C1-C6alcényle, C1-C6alcanoyle, halogène, cyano, -C(O)C1-C6alkyle, -C1-C6alkylèneCN, -C1-C6alkylèneNR'R dans laquelle R' et R représentent chacun indépendamment hydrogène ou C1-C6alkyle, -C1-C6alkylèneOC(O)C1-C6alkyle, ou -CH(OH)R4 dans laquelle R4 représente hydrogène ou C1-C6alkyle; R2 représente hydrogène, C1-C6alkyle éventuellement substitué par halogène, hydroxy ou benzyloxy, C1-C6alcényle, C1-C6alcynyle, -CO2C1-C6alkyle, ou -R5-NR'R dans laquelle R5 représente C1-C6alkylène, C1-C6alcénylène ou C1-C6alcynylène et R' et R représentent chacun indépendamment hydrogène, C1-C6alkyle ou alternativement le groupe -NR'R dans son entier représente 1-pyrrolidinyle; et R3 représente hydrogène, nitro, amino, halogène, C1-C6alcoxy, hydroxy ou C1-C6alkyle, ou un sel acceptable sur le plan pharmaceutique dudit composé.

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