Method of treating sjogren's syndrome

Details Method of treating sjogren's syndrome Method of treating sjogren's syndrome

A - Human Necessities

61

P

A61P 37/00 (2006.01) A61K 39/395 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2573359

A method of treating Sjögren's syndrome in a patient eligible for treatment is provided involving administering an effective amount of an antagonist that binds to a B-cell surface marker to the patient to provide significant improvement over baseline in two or more of dryness, fatigue, and joint pain on a Visual Analogue Scale, and an article of manufacture therefor. Methods and articles are also provided involving treating Sjögren's syndrome in a subject eligible for treatment is provided involving administering an effective amount of an antibody that binds to a B-cell surface marker to the subject to provide an initial exposure and a subsequent exposure to the antibody within certain dosing regimens and an article of manufacture therefor.

Un procédé pour traiter le syndrome de Sjögren chez un patient nécessitant un tel traitement consiste à administrer une quantité efficace d'un antagoniste qui se lie à un marqueur de surface de cellule B chez le patient de manière à assurer une amélioration sensible par rapport à la référence de base de la sensation de sécheresse, de la fatigue et des douleurs des articulations sur l'échelle analogue visuelle, ainsi qu'un article de fabrication correspondant. L'invention concerne des procédés et des articles destinés à traiter un syndrome de Sjögren chez un sujet nécessitant un tel traitement, les procédés consistant à administrer une quantité efficace d'un anticorps qui se lie à un marqueur de surface des cellules B chez le sujet pour assurer une exposition initiale et une exposition ultérieure à l'anticorps avec certains régimes de dosage, de même qu'article manufacturé correspondant.

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