Method of treating staphylococcus aureus infection

A - Human Necessities – 61 – K

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A61K 39/085 (2006.01) A61K 39/02 (2006.01)

Patent

CA 2594533

The present invention provides a method of preventing or treating bacteremia caused by Staphylococcus aureus, comprising administering a monoclonal or polyclonal antibody composition comprising antibodies specific for one or more S. aureus antigens. In one specific embodiment, the composition is a hyperimmune specific IGIV composition. In another specific embodiment, the composition comprise antibodies to a capsular polysaccharide S. aureus antigen, such as the Type 5 and/or Type 8 antigens. In another embodiment, the composition comprises monoclonal antibodies to a capsular polysaccharide S. aureus antigen. This method provides an effective tool for preventing or treating S. aureus bacteremia, and can be used alone or in combination with other therapies.

L'invention concerne une méthode de prévention ou de traitement de bactérémies causées par le staphylocoque doré qui consiste à administrer une composition d'anticorps monoclonaux ou polyclonaux qui renferme des anticorps spécifiques à un ou plusieurs antigènes S. doré. La composition peut être une composition IGIV spécifique hyperimmune ou encore renfermer des anticorps dirigés contre un antigène de S. doré de polysaccharide capsulaire, notamment des antigènes du type 5 et/ou du type 8. La composition peut encore comprendre des anticorps monoclonaux dirigés contre un antigène de staphylocoque doré de polysaccharide capsulaire. Cette méthode est efficace pour éviter ou traiter les bactérémies par staphylocoque doré et peut être utilisé seul ou en combinaison avec d'autres thérapies.

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