Method of treating symptoms of hormonal variation, including...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/195 (2006.01) A61K 31/138 (2006.01) A61K 31/197 (2006.01)

Patent

CA 2378918

One aspect of the present invention relates to a method of treating hot flashes in a patient which is carried out by providing a compound which binds a .alpha.2.delta. subunit of a voltage-gated calcium channel and administering the compound to a patient experiencing hot flashes under conditions effective to treat the hot flashes. Another aspect of the present invention relates to a method for treating a symptom of hormonal variation in a patient which is carried out by providing a compound which binds a .alpha.2.delta. subunit of a voltage-gated calcium channel and administering the compound to a patient experiencing a symptom of hormonal variation under conditions effective to treat the symptom of hormonal variation. Further aspects of the present invention relate to the administration of a compound which binds a .alpha.2.delta. subunit of a voltage-gated calcium channel as an anti-pyretic agent (for treating fever) or as an anti-emetic agent (for treating nausea and emesis).

La présente invention concerne, dans un aspect, une méthode de traitement de bouffées de chaleur chez un patient, la méthode consistant à prendre un composé se liant à une sous-unité alpha 2 delta d'un canal calcique dépendant d'un potentiel d'action, puis à administrer ce composé à un patient souffrant de bouffées de chaleur, dans des conditions appropriées de traitement de bouffées de chaleur. Dans un autre aspect, la présente invention concerne une méthode de traitement d'un symptôme de variations hormonales chez un patient, la méthode consistant à prendre un composé se liant à une sous-unité alpha 2 delta d'un canal calcique dépendant d'un potentiel d'action, puis à administrer ce composé à un patient présentant des symptômes de variations hormonales, dans des conditions appropriées de traitement de symptômes de variations hormonales. Dans d'autres aspects encore, la présente invention concerne l'administration d'un composé se liant à une sous-unité alpha 2 delta d'un canal calcique dépendant d'un potentiel d'action comme agent antipyrétique (pour le traitement de la fièvre) ou agent antiémétique (pour le traitement des nausées et vomissements).

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