A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 51/00 (2006.01) A61K 38/12 (2006.01) A61K 51/10 (2006.01) C07K 7/56 (2006.01) C07K 16/30 (2006.01)
Patent
CA 2493172
A method of treating tumors, such as prostate tumors, breast tumors, non- Hodgkin's lymphoma, and the like, includes the sequential steps of administering to the patient at least one dose of an antiangiogenic cyclo- arginine-glycine-aspartic acid-containing pentapeptide (cRGD pentapeptide); administering to the patient an anti-tumor effective amount of a radioimmunotherapeutic agent (RIT); and then administering to the patient at least one additional dose of cRGD pentapeptide. The cRGD pentapeptide is preferably cyclo-(Arg-Gly-Asp-D-Phe-[N-Me]-Val), and the RIT is preferably a radionuclide-labeled chelating agent-ligand complex in which chelating agent is chemically bonded to a tumor-targeting molecule, such as a monoclonal antibody.
L'invention concerne une méthode pour traiter les tumeurs, telles que les tumeurs de la prostate, les tumeurs du sein, le lymphome non Hodgkinien et analogues, comprenant les étapes suivantes : administrer au moins une dose d'un pentapeptide antiangiogénique contenant un acide cyclo-arginine-glycine-aspartique (pentapeptide cRGD) à un patient ; administrer au patient une quantité efficace anti-tumorale d'un agent radioimmunothérapeutique (RIT) ; et administrer au patient au moins une dose supplémentaire de pentapeptide cRGD. Ledit pentapeptide cRGD est de préférence cyclo-(Arg-Gly-Asp-D-Phe-[N-Me]-Val), et le RIT est de préférence un complexe ligand-agent de chélation marqué par radionucléides, dans lequel l'agent de chélation est lié chimiquement à une molécule de ciblage tumoral, telle qu'un anticorps monoclonal.
Burke Patricia A.
Denardo Gerald L.
Denardo Sally J.
Goodman Simon
Matzku Siegfried
Cassan Maclean
Merck Patent Gmbh
The Regents Of The University Of California
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