Method of treating undesired uterine contractions using...

A - Human Necessities – 61 – K

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A61K 31/135 (2006.01) A61K 31/137 (2006.01) A61K 31/138 (2006.01)

Patent

CA 2247953

A method of preventing or inhibiting undesired uterine contractions in a female individual by administering a pure eutomer of an adrenergic beta-2 agonist which relaxes uterine smooth muscle, while eliminating side effects caused by the distomer. The method is particularly useful in treating both pregnant and non-pregnant subjects that have demonstrated a propensity for undesired uterine contractions, while reducing side effects in the patients and/or their fetuses, such as bronchial hyperreactivity, tremor, nervousness, shakiness, dizziness, increased appetite and cardiac tachycardia. Importantly, administration of a pure eutomer also eliminates undesired contractions of the uterine smooth muscle while avoiding the uterine hyperreactivity that has now been found to be induced by the S- or SS-isomers of beta-2 agonists.

La présente invention concerne un procédé de prévention ou d'inhibition des contractions utérines indésirables chez la femme. Ce procédé consiste en l'administration d'un eutomère pur d'un agoniste .beta.-2 adrénergique provoquant le relâchement du muscle lisse utérin, tout en éliminant les effets secondaires imputables au distomère. Le procédé convient particulièrement au traitement des patientes enceintes ou non enceintes qui ont fait preuve d'une propension aux contractions utérines indésirables, tout en réduisant chez ces patientes et/ou leur foetus les effets secondaires tels que l'hyperréactivité bronchique, le tremblement, la nervosité, les pertes d'équilibre, les vertiges, la boulimie et la tachycardie cardiaque. Il est à remarquer que l'administration d'un eutomère pur élimine également les contractions indésirables du muscle lisse de l'utérus, tout en évitant l'hyperréactivité utérine qui s'est avérée être induite par les isomères S ou SS des agonistes .beta.-2.

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