A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 38/17 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2737280
The invention provides methods for inducing apoptosis. comprising treatment of a patient with a TNF.alpha. inhibitor as well as with an IAP inhibitor and a TRAIL receptor agonist. The methods ameliorate the risk of unwanted effects, thereby resulting in an improved therapeutic index for IAP inhibitors in combination with a TRAIL receptor agonist.
La présente invention concerne des procédés d'induction de l'apoptose, comprenant le traitement d'un patient au moyen d'un inhibiteur du TNFa, ainsi que d'un inhibiteur de l'apoptose (IAP) et que d'un agoniste du récepteur TRAIL. Ces procédés limitent les risques d'effets indésirables, ce qui a pour résultat un indice thérapeutique amélioré pour les inhibiteurs IAP associés à un agoniste du récepteur TRAIL.
Benetatos Christopher A.
Chunduru Srinivas K.
Holland Pamela M.
Mckinlay Mark A.
Piasecki Julia C.
Amgen Inc.
Goudreau Gage Dubuc
Tetralogic Pharmaceuticals
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