Method of treatment of age-related macular degeneration

Details Method of treatment of age-related macular degeneration Method of treatment of age-related macular degeneration

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 35/28 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 38/16 (2006.01) A61K 38/20 (2006.01) A61K 45/00 (2006.01)

Patent

CA 2656463

The invention provides methods and compositions for treatment of age-related macular degeneration, which comprises causing T cells that produce IL-4 to accumulate in the eye by administration of an agent such as Copolymer-1, IL-4, cells activated with IL-4, IL-13 or up to 20 ng/ml IFN-g, or a pathogenic self-antigen associated with a T-cell-mediated specific autoimmune disease of the eye or a peptide derived therefrom, and any combination of such agents.

L'invention concerne des compositions et des méthodes de traitement de la dégénérescence maculaire liée à l'âge, consistant à faire s'accumuler dans l'oeil des lymphocytes T produisant l'IL-4, en administrant un agent, tel que le copolymère-1, l'IL-4, des cellules activées avec l'IL-4, l'IL-13 ou jusqu'à 20 ng/ml d'IFN-g, ou un auto-antigène pathogène associé à une maladie auto-immune spécifique de l'oeil médiée par des lymphocytes T, ou un peptide dérivé de ce dernier, et toute association d'agents de ce type.

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