Method of treatment of diseases by deletion of t cells

Details Method of treatment of diseases by deletion of t cells Method of treatment of diseases by deletion of t cells

A - Human Necessities

61

K

A61K 39/00 (2006.01) A61K 38/16 (2006.01) A61K 39/085 (2006.01)

Patent

CA 2159891

This invention includes the discovery that chronic exposure to the superantigen (SAg) staphylococcal enterotoxin (SEA) causes almost complete deletion of target T cells in vivo. Mice were either acutely or chronically exposed to varying doses of SEA, and the relative level of T cells bearing SEA-reactive V.beta. elements was followed over time in lymphocytes purified from peripheral blood, lymph nodes, mesenteric lymph nodes, and spleen. Acute exposure caused the disappearance of 50-70 % of reactive T cells. Chronic exposure caused almost complete deletion of target T cells. Deletion was evident even in animals treated with very low doses of SEA, doses too small to cause any apparent T cell proliferation. Thus, proliferation does not appear to be a prerequiste for peripheral deletion of T cells and peripheral tolerance may be achieved by chronic exposure to low levels of antigen without prior cell division.

Affiliated with

Also associated with

Rating

Method of treatment of diseases by deletion of t cells does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of treatment of diseases by deletion of t cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of treatment of diseases by deletion of t cells will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1566180