Method of treatment using, process of preparing, and...

C - Chemistry – Metallurgy – 12 – N

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C12N 15/86 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 14/72 (2006.01) C12N 5/10 (2006.01) C12N 15/869 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2176284

Methods for treatment, processes for preparing, and compositions for delivering nucleic acid segments to non-mitotic cells, primarily of the treatment of neurological disorders and exploring neurological functions, are disclosed. In particular, the invention provides recombinant HSV-1 with a high rate of expression of foreign nucleic acid segments and or a low cytopathicity and its associated methods and processes.

Procédés de traitement, techniques de préparation, et compositions permettant de libérer des segments d'acide nucléique dans des cellules non mitotiques, principalement pour le traitement de troubles neurologiques et l'exploration des fonctions neurologiques. L'invention concerne plus particulièrement un herpesvirus-1 présentant une vitesse élevée d'expression de segments d'acide nucléique étranger et/ou une faible cytopathicité, ainsi que les techniques et procédés associés.

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