Method of using (2-imidazolin-2-ylamino) quinoxalines in...

A - Human Necessities – 61 – K

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A61K 31/495 (2006.01) A61K 31/498 (2006.01)

Patent

CA 2225626

A method according to which neuroprotection is conferred upon ocular nerve cells by administration of a drug of formula (I) to the optic nerve and/or retina of a mammal within a period prior to or following an insult to ocular nerve cells but prior to cell death, wherein the 2-imidazolin-2-ylamino group may be in either the 5- or 6-position of the quinoxaline nucleus; x, y and z may be in any of the remaining 5-, 6-, 7- or 8-positions and are selected from hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl; and R is an optional substituent in either the 2- or 3-position of the quinoxaline nucleus and may be hydrogen, lower alkyl or lower alkoxy is disclosed.

Ce procédé permet de conférer une neuroprotection aux cellules du nerf oculaire, par l'administration, sur le nerf optique et/ou la rétine d'un mammifère, dans une période précédant ou suivant une agression contre les cellules du nerf optique, mais avant la mort cellulaire, d'un médicament de formule (I), où le groupe 2-imidazolin-2-ylamino peut se trouver en position 5- ou 6- du noyau de quinoxaline; x, y et z peuvent se trouver en l'une ou l'autre des positions 5-, 6-, 7- ou 8- restantes et sont choisis parmi hydrogène, halogène, alkyle inférieur, alcoxy inférieur ou trifluorométhyle; et R représente un substituant facultatif, placé en position 2- ou 3- du noyau quinoxaline, qui peut être hydrogène, alkyle inférieur ou alcoxy inférieur.

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