C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/26 (2006.01) A61K 39/395 (2006.01) C07K 14/59 (2006.01) C07K 16/30 (2006.01) C12N 5/00 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2132868
The invention provides a method of lysing malignant cells, which comprises contacting the malignant cells with an antib-ody which specifically reacts with an epitope present on the beta subunit of human chorionic gonadotropin and/or beta subunit fragment,under conditions such that the malignant cells lyse. This invention further provides a method of quantitatively measur-ing malignant cells or a method of obtaining an enriched population of malignant cells, which comprises contacting live malig-nant cells to be measured or contacting a population of cells comprising live malignant cells with an antibody directed to an ep-itope of human chorionic gonadotropin, its subunits and/or subunit fragments, under conditions such that the antibody is capable of forming a complex with the epitope if present on the cell surface, and detecting the presence of any complex formed using fluorescence activated cell sorting technology, the presence of such complex on the surface of the cells indicating that the cells are malignant, and isolating the cells which form a complex with the antibody.
Acevedo Hernan
Krichevsky Alexander
Allegheny-Singer Research Institute
Smart & Biggar
The Trustees Of Columbia University
The Trustees Of Columbia University In The City Of New York
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