A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/495 (2006.01) A61K 31/496 (2006.01) A61P 7/02 (2006.01) C07D 241/04 (2006.01)
Patent
CA 2417960
The invention provides a method of inhibiting the effects of platelet activating factor (PAF). For instance, a disease or condition mediated by PAF (particularly inflammation) can be treated or platelet aggregation can be inhibited. The invention also provides a method of inhibiting the production and/or release of interleukin 8 (IL-8) by cells. The effects of PAF and the production and/or release of IL-8 are inhibited according to the invention by a compound of formula (1) wherein R1 and R2 are defined in the application, or a physiologically-acceptable salt thereof. The invention also provides pharmaceutical compositions comprising these compounds.
Cette invention concerne une méthode qui inhibe les effets du facteur d'activation des plaquettes (PAF). Par exemple. Une maladie ou une affection induite par PAF (notamment une inflammation) peut être traitée ou une agrégation plaquettaire inhibée. L'invention concerne également une méthode qui inhibe la production et/ou favorise la libération de l'interleukine 8 (IL-8) par des cellules. Les effets de PAF et la production et libération d'IL-8 ssont inhibés, selon l'invention, par un composé de la formule (I) dans laquelle R?1¿ et R?2¿ sont tels que définis dans le mémorandum descriptif, ou un sel pharmaceutiquement acceptable dudit composé. L'invention concerne en outre des compositions pharmaceutiques contenant ces composés.
Bar-Or David
Curtis C. Gerald
Rao Nagaraja K. R.
Thomas Greg
Dmi Biosciences Inc.
Parlee Mclaws Llp
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