Method of using extracts of epimedium species

Details Method of using extracts of epimedium species Method of using extracts of epimedium species

A - Human Necessities

61

K

A61K 36/296 (2006.01) A61P 9/00 (2006.01) A61P 15/12 (2006.01) A61P 19/10 (2006.01) A61P 35/00 (2006.01) C12N 15/00 (2006.01) C12N 15/63 (2006.01) C12N 15/113 (2010.01) C12N 15/85 (2006.01)

Patent

CA 2588180

Extracts of various species of the family Berberidaceae have estrogenic properties. For example, aqueous and ethanolic extracts of Epimedium species possess estrogenic properties in both ER.alpha.+ and ER.beta.+ cells. These estrogenic effect include estrogen response element (ERE) stimulation as well as tumor necrosis factor (TNF) repression. Methods are provided for treating climacteric symptoms, breast and/or uterine cancer, and osteoporosis.

les extraits de différentes espèces de la famille des Berberidaceae présentent des propriétés oestrogéniques. Par exemple les extraits aqueux et éthanoliques des espèces du genre Epimedium présentent les propriétés oestrogéniques des cellules ERa+ et ERß+. Ces effets comprennent la stimulation de l'élément de réponse aux oestrogènes (ERE) et la répression du facteur de nécrose tumorale (TNF). L'invention porte également sur des procédés de traitement des symptômes climatériques, des cancers du sein et de l'utérus, et de l'ostéoporose.

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